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Symbol
Name
ID 		Tgfb1
transforming growth factor, beta 1
MGI:98725
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgG level
Decreased circulating antibody level
Paraproteinemia
Bleeding with minor or no trauma
Epistaxis
Gingival bleeding
Gastrointestinal hemorrhage
Hematemesis
Melena
Intracranial hemorrhage
Intraventricular hemorrhage
Joint hemorrhage
Muscle hemorrhage
Oral cavity bleeding
Persistent bleeding after trauma
Bruising susceptibility
Purpura
Petechiae
Spontaneous hematomas
Bone marrow hypocellularity
Aplastic anemia
Anemia
Eosinophilia
Thromboembolism
Superficial thrombophlebitis
Reduced factor VIII activity
Prolonged partial thromboplastin time
Multiple myeloma
Elevated erythrocyte sedimentation rate
Splenic rupture
Splenomegaly
Hepatosplenomegaly
Disease(s) Associated with TGFB1
aplastic anemia
Behcet's disease
Camurati-Engelmann disease
cystic fibrosis
eosinophilic esophagitis
factor VIII deficiency
multiple myeloma

Mouse Phenotypes
increased T cell proliferation
abnormal embryonic hematopoiesis
abnormal embryonic erythropoiesis
decreased thymus weight
thymus hypoplasia
abnormal T cell differentiation
abnormal T-helper 17 cell differentiation
decreased Langerhans cell number
absent Langerhans cell
abnormal T cell subpopulation ratio
increased T-helper 1 cell number
decreased T-helper 17 cell number
decreased CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha-beta T cell number
increased regulatory T cell number
increased monocyte cell number
increased leukocyte cell number
abnormal T cell morphology
decreased spleen weight
small spleen
spleen hypoplasia
abnormal T cell activation
abnormal regulatory T cell physiology
Availability Mouse Genotype
Tgfb1tm1(Tgfb3)Kul/Tgfb1tm1(Tgfb3)Kul
Tgfb1tm1Doe/Tgfb1tm1Doe
Tgfb1tm1N/Tgfb1tm1N
Tgfb1tm1Rif/Tgfb1tm1Rif
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?  (conditional)
B9d2/Tgfb1tm1Flv/B9d2/Tgfb1tm1Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
Tg(Lck-cre)548Jxm/?
Tgfb1tm2.1Doe/Tgfb1tm2.1Doe  (conditional)
Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tg(Cd4-cre)1Cwi/0  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Tnfrsf4tm2(cre)Nik/Tnfrsf4+  (conditional)
B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv
Foxp3tm4(YFP/icre)Ayr/Foxp3+  (conditional)
Tgfb1tm2Flv/B9d2/Tgfb1tm1Flv
Tg(CD207-cre)1Dhka/?  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory